Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal Barrier
نویسندگان
چکیده
منابع مشابه
Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients
Background: Increased number of intestinal intraepithelial lymphocytes (IELs) is a key histological finding in the diagnosis of celiac disease (CD); however, the number of IELs in celiac patients and healthy subjects may vary from one region to another. Additionally, there are some seronegative celiac patients with a borderline histology. Objective: To determin...
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BACKGROUND Alemtuzumab has been used in organ transplantation and a variety of hematologic malignancies (especially for the treatment of B-cell chronic lymphocytic leukemia). However, serious infectious complications frequently occur after treatment. The reason for increased infections postalemtuzumab treatment is unknown at this stage. We explore the effect of alemtuzumab on intestinal intraep...
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The interaction of mucosal lymphocytes and intestinal epithelial cells is thought to be important in regulating immune response in the intestinal mucosa, but conclusive evidence is limited. Here we demonstrate the expression of IL-7 mRNA in human intestinal mucosa by combined reverse transcription PCR and Southern blot hybridization. Immunohistochemistry and in situ hybridization confirm the pr...
متن کاملIntestinal intraepithelial lymphocytes: the plot thickens
O ver the last few years, the characterization of T lyraphocytes within the intestinal epithelium (ilEL) has revealed phenotypic and functional heterogeneity that rivals only that observed within the thymus. Of note in this context is that thymic and intestinal epithdia share the same embryologic origin in that they are both derived from endoderm. Several lines of evidence have led to the concl...
متن کامل[Epithelial cells as sentinels in mucosal immune barrier].
The mucosal surface of the body is exposed to a vast array of exogenous antigens and microorganisms. Epithelial cells evoke minimal immune response to food ingredients and commensal bacteria, while they release an array of antimicrobial peptides and CXC chemokines in response to bacterial invasion or inflammatory stimuli. The mucosal antigens are transported from the gut lumen to organized lymp...
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ژورنال
عنوان ژورنال: Trends in Immunology
سال: 2018
ISSN: 1471-4906
DOI: 10.1016/j.it.2017.11.003